Property of the family since the 11th century, Castiglioni is the point of origin of wine production for the Frescobaldis. Documentation indicates that wines were being produced here as early as 1300. The estate extends along the ancient Via di Castiglioni, built by the Romans to unify northern Tuscany and Rome.

The area was already famous in those times for the quality of its agricultural harvests and was for centuries at the center of heavy trade traffic and chosen as the site for luxury Roman villas. The coat of arms of the Frescobaldi family, with the crown, the shield and three fortresses, represents Castiglioni as well, in remembrance and recognition of the 700 years of wine-making history which began here at this very estate.